Why use irradiated blood

Continued observation of new immunosuppressive regimes is required and guidelines updated in accordance with emerging data. Refer to individual institutional policy. Skip to main content. Products Blood components Modified blood components Irradiated components Irradiated components Irradiated blood components are used to prevent Transfusion-associated graft-versus host disease TA-GVHD the primary cause of which is proliferation and engraftment of transfused donor T-lymphocytes in the bone marrow of susceptible recipients.

Side effects and hazards Ionising irradiation of red cells causes an increase in the level of extracellular potassium. When should I use irradiated components? Haematology Hodgkin lymphoma Patients should receive irradiated cellular components throughout entire disease management. Patients receiving alemtuzumab for malignant and non malignant disorders and transplants Patients should receive irradiated cellular components. About AABB. Contact Us. Corporate Services.

Get Involved. Donor Safety, Screening and Testing. Plasma Components. Platelet Components. Regulatory Resources for Transfusion Services. Chagas Disease. West Nile Virus. Zika Virus. Emerging Infectious Disease Agents. Blood Products Advisory Committee. These donor lymphocytes proliferate and damage target organs, especially bone marrow, skin, liver and gastrointestinal tract. Typically the condition presents days after transfusion with rash erythroderma , pancytopenia and abnormal liver function.

There is a longer time between transfusion and presentation in neonates. The risk with an individual transfusion depends on a number of factors including, the viability of contaminating lymphocytes in the blood product, the susceptibility of the recipient's immune system to their engraftment, and the degree of immunologic disparity between the donor and recipient.

TA-GVHD was originally recognised as a complication of intrauterine transfusion and transfusion to recipients of allogeneic bone marrow transplants. Leukocyte depletion using current technology is inadequate for this purpose. Irradiation of blood products is undertaken using a dedicated blood irradiator located onsite with a long half-life gamma emitting source.

Irradiation of blood products will take a further 4 - 5 minutes to provide. If blood products are needed urgently or in the case of an MTP, the products may not be able to be irradiated in a timely manner. Un-irradiated products will be provided in this case. Irradiation of red blood cells and whole blood results in reduced post transfusion red cell recovery and increases the rate of efflux of intracellular potassium.

Blood 26 3 Guidelines on the use of irradiated blood components prepared by the British Committee for Standards in Haematology blood transfusion task force. Brit J Haematol Microchimerism, GVHD, and tolerance in solid organ transplantation. Transfusion Improvement of kidney graft survival with increased numbers of blood transfusions.

G Opelz and PI Terasaki. N Engl J Med 15 We thank you for your interest in donating blood and helping your community. This convention likely arose from the finding that platelets stored at refrigerator temperatures have Read more. Surveillance data on platelets stored Read more. There were several changes and additions of note, a few Read more.

With origins in the s, Carter BloodCare is one of Texas' largest blood centers, providing over , units of life-saving blood and blood components to patients in North, Central, and East Texas annually. Carter BloodCare Blog. Next Previous.