What does pdx1 stand for

Images are representative of at least 10 different islets. However, by 3 Fig. No significant reduction in the number of islets was observed in the mutant mice data not shown. Transgene expression is known to vary between transgenic lines and also between cells in a given transgenic line Martin and Whitelaw ; Kioussis and Festenstein The homeodomain protein Nkx6.

Interestingly, Nkx6. The loss of Nkx6. The diabetic mutants responded to insulin administration by transiently reverting to normoglycemia data not shown , excluding insulin resistance as a cause of diabetes. Glut2 -deficient mice show an impaired glucose-induced insulin secretion and develop diabetes Guillam et al. Thorens, pers. A strong family history of early onset type II diabetes is associated with heterozygosity for a point mutation in the human Ipf1 gene Stoffers et al.

The glucose intolerance could reflect either impaired insulin, Glut2 expression, or both. Blood glucose levels are shown at indicated time points after IP administration of glucose. Loss of the early function results in an inability to form a pancreas Jonsson et al.

The two loxP sites Kilby et al. Similarly, the downstream loxP recognition and core sequence has Nco I sites at its ends and an internal Pst I site. The internal sites were used to verify homologous recombination. The functionality of the targeting construct was verified by incubating the final 8.

Bands corresponding to 8. E ES cells Jonsson et al. Blood samples were obtained from the tail vein, and glucose levels were measured immediately before and 15, 30, 45, 60, 90, , and min after injection using a Glucometer Elite Bayer, Inc. Pancreatic insulin was measured using a commercially available radioimmuno assay for rat insulin Linco , and total pancreatic protein concentration was determined using the Bio-Rad protein assay.

Immunohistochemistry and confocal image analysis was performed essentially as described previously Ahlgren et al. We thank K. Falk, U. Backman, and I. Berglund for skillful technical assistance; Drs. GeneReviews: Not available. Variation Go to the top of the page Help. Pathways from PubChem Go to the top of the page.

Interactions Go to the top of the page Help. General gene information Go to the top of the page Help. Inferred from Biological aspect of Ancestor more info. Inferred from Sequence Alignment more info. Inferred from Electronic Annotation more info.

Inferred from Direct Assay more info. Inferred from Sequence or Structural Similarity more info. Traceable Author Statement more info. General protein information Go to the top of the page Help. Explain These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Explain This section includes genomic Reference Sequences RefSeqs from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds contigs from both reference and alternate assemblies.

Reference GRCh Related sequences Go to the top of the page Help. Browse Tocris compounds for PDX1. ApexBio compounds for PDX1. This gene is overexpressed in Pancreas x This gene is overexpressed in Pancreas Show more. Protein tissue co-expression partners for PDX1 Gene. Tissue specificity: Duodenum and pancreas Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells.

Pancreas 4. Germ Layers: ectoderm endoderm mesoderm. Systems: cardiovascular digestive endocrine immune integumentary nervous reproductive skeletal muscle skeleton urinary. Regions: Head and neck: brain ear eye eyelid face forehead head lip nose skull.

Thorax: chest wall heart. Abdomen: abdominal wall intestine kidney large intestine pancreas small intestine. Pelvis: penis placenta uterus. Limb: ankle digit elbow finger foot hand hip knee lower limb shoulder toe upper limb wrist.

General: blood blood vessel peripheral nerve peripheral nervous system skin white blood cell. This gene was present in the common ancestor of animals. Orthologs for PDX1 Gene. All consequence types are included: molecular consequences e.

Variation tolerance for PDX1 Gene. Category Lineage enriched Group enriched Lineage enhanced Low lineage specificity Not detected Detected in all Detected in many Detected in single Is highest expressed.

Prognosis Favorable Unfavorable. Antibodies Yes No. Tissue proteome. General description of the gene and the encoded protein s using information from HGNC and Ensembl , as well as predictions made by the Human Protein Atlas project.

Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. Assigned HPA protein class es for the encoded protein s. Read more. All transcripts of all genes have been analyzed regarding the location s of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data , have been further annotated and classified with the aim to determine if the corresponding protein s are secreted or actually retained in intracellular locations or membrane-attached.

Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location s. Number of protein-coding transcripts from the gene as defined by Ensembl.

Summary of data presented in the Tissue Atlas and representative images of protein expression left and mRNA expression right. The images are clickable and will redirect to more Tissue Atlas data. The Tissue Atlas contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level.

The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.

The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. View primary data.

Standardized explanatory sentences with additional information required for full understanding of the protein expression profile, based on knowledge-based and secretome-based annotation. The reliability score is based on the 44 normal tissues analyzed, and if there is available data from more than one antibody, the staining patterns of all antibodies are taken into consideration during evaluation.

Antibodies used for this assay. Click on an antibody for more information. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar.

Subsequent selection of a particular tissue in this list links to the image data page. All organs. To access sample data, click on tissue name or bar. Each bar represents the highest expression score found in a particular group of tissues. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression. Cerebral cortex. Lymph node. For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview.

However, all immunohistochemical images are still available and the annotation data can be found under Primary data. RNA tissue specificity: Group enriched gallbladder, intestine, pancreas.